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KMID : 0880220170550060483
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Journal of Microbiology
2017 Volume.55 No. 6 p.483 ~ p.487
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Bedaquiline susceptibility test for totally drug-resistant tuberculosis Mycobacterium tuberculosis
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Jang Ji-Chan
Jung Yong-Gyun
Choi Jung-Il
Jung Hyun-Ju
Ryoo Sung-Weon
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Abstract
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This study aimed to provide information that bedaquilline is significantly effective for treatment of totally drug resistant (TDR) Mycobacterium tuberculosis that shows resistant to all first- and second-line drugs-using an innovative disc agarose channel (DAC) system. Time-lapse images of single bacterial cells under culture conditions with different concentrations of bedaquiline were analysed by image processing software to determine minimum inhibitory concentrations (MICs). Bedaquiline inhibited the growth of TDR M. tuberculosis strains, with MIC values ranging from 0.125 to 0.5 mg/L. The results of the present study demonstrate that bedaquiline, newly approved by the United States Food and Drug Administration (FDA), may offer therapeutic solutions for TDR-TB.
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KEYWORD
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bedaquiline, Mycobacterium tuberculosis, totally drug resistant Mycobacterium tuberculosis
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